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San Francisco 49ers at Los Angeles Chargers on August 22, 2021

San Francisco 49ers at Los Angeles Chargers, August 22, 2021

On Sunday, August 22, at 4:30 p.m., the Bolts host San Francisco — the Chargers' most frequent preseason opponent — in Week 2 of the preseason for the first time since 2016.

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History: Los Angeles Chargers vs San Francisco 49ers

Los Angeles has posted 22 wins against the 49ers, the team's most wins against a single preseason opponent, and is riding a two-game winning streak.

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