History: Los Angeles Chargers at Buffalo Bills
- All Time Record: The Chargers are 24-10-2 against the Bills.
- Interesting Fact: Winners of four-straight games against the Bills, Los Angeles visits Buffalo for the second time in three seasons. Over that four-game streak, the Chargers have picked off 10 Bills pass attempts.
- Streaks:The Bolts have won 4-straight games and 6 of the last 7 against Buffalo.
- 2018 Results: The Chargers defeated the Bills 31-20 on December 1, 2019.