Note: The story was updated on September 11.

The Chargers are big home favorites ahead of their Week 1 matchup against the Cardinals.

The Bolts open the season in Southern California for their first regular-season game of 2026, with kickoff at 1:25 p.m. (PT) from SoFi Stadium.

The Chargers enter the game favored over the Cardinals by the Vegas books as of Friday morning.

The Bolts are 9.5-point favorites according to DraftKings Sportsbook, FanDuel Sportsbook, Caesars Sportsbook and Bet365. They are also 9-point favorites according to BetMGM and Fanatics Sportsbook.

In terms of the over/under, every sportsbook has the total above 47 points.

Caesars Sportsbook, DraftKings, FanDuel Sportsbook, Fanatics Sportsbook, BetMGM and Bet365 all have the total at 47.5.