The San Diego Chargers fell to the Indianapolis Colts 26-22. The Colts scored on their opening possession with kicker Adam Vinatieri booting a 38-yard field goal to give the home team the 3-0 lead. Indianapolis increased their lead 10-0 after Frank Gore rushed up the middle on second down for a six-yard score. The Bolts' first points of the game came when Josh Lambo booted a 42-yard field goal. Lambo then tacked on three more, four plays after Casey Hayward picked off Andrew Luck. The field goal flurry didn't stop there. Vinatieri made it 13-6 after making a 33 yarder. San Diego was driving downfield, but committed their first red zone turnover in 16 games after Erik Walden came in to strip-sack Rivers. The Colts recovered the fumble; however, five plays later, Caraun Reid scored a defensive touchdown for the Bolts as Jatavis Brown sacked and stripped Luck. Reid picked up the fumble and ran it back 61 yards to tie the game.
Melvin Gordon scored the Bolts' first touchdown of the day capping off a 12-play, 80-yard drive. After a missed extra point, the Bolts took the lead, 19-13. The Colts then regained the lead after Robert Turbin ran it in for a one-yard score. After getting down to the Colts' nine-yard line, Lambo made it 22-20 after a 27-yard field goal. Two plays after converting a fourth down, Andrew Luck found T.Y. Hilton who took the ball 63 yards into the end zone. After a failed two-point conversion, Indy regained the lead 26-22. The Chargers then started driving with just over a minute to play, but on second down, Clayton Geathers came in to pop the ball free from Hunter Henry's arms and the Colts recovered to ultimately walk out of their stadium with a win.
8:58 – After getting downfield, Adam Vinatieri kicked a 38-yard field goal for the 3-0 lead.
5:42 – Andrew Luck found T.Y. Hilton deep down the middle for a gain of 24.
4:39 – Vinatieri kicked a 55-yard field goal, but the Chargers were called for leverage to give the Colts a new set of downs.
3:43 – Three plays after the penalty, Frank Gore rushed up the middle for a six-yard touchdown.
15:00 – The Colts challenged the Bolts' first down spot, which came at the end of the first quarter, and won to bring up a 3rd-and-1.
14:56 – Josh Lambo made a 42-yard field goal to give the Chargers their first points of the game.
14:45 – Casey Hayward jumped in front of the Colts receiver to pick off Luck. Four plays later, Josh Lambo tacked on three more after making a 34-yd FG.
7:11 – On third down, Denzel Perryman came in to sack Luck for a loss of three before he was able to take off and run.
6:30 – Vinatieri increased the Colts' lead 13-6, with a 33-yard FG.
4:25 – Rivers found rookie tight end Hunter Henry, who then took the pass down the right sideline for a gain of 33.
1:56 – On third down, Erik Walden came around to sack and strip Rivers. The Colts recovered the fumble on their own 23.
1:08 – Jatavis Brown sacked and stripped Luck. Caraun Reid then took the ball into the end zone for a 61-yard score to make it 13-13.
14:48 – Tyrell Williams took a Rivers' pass up the middle for a 22-yard gain.
11:11 – Williams again took a pass from number 17, this one good for 19.
8:27 – Melvin Gordon had the Chargers' first touchdown of the day with a one-yard score.
6:23 – Luck dropped back and lobbed a pass deep to Hilton, who made a leaping grab good for 33 yards.
2:43 – Robert Turbin ran off right guard for a one-yard score.
14:20 – On 2nd-and-20, Luck hit Chester Rogers who seemed to have made a 58-yard reception, however the WR was called for offensive pass interference and the play was negated.
11:18 – Gordon took a pass from Rivers up the left sideline for a gain of 25.
10:15 – Rivers found Benjamin for a gain of 43; however, after an unsportsmanlike conduct penalty, the 15-yard flag backed the Bolts up to the IND 22.
8:24 – Walden got to Rivers again. This sack was good for a loss of six.
7:38 – After the sack, Lambo came out and made a 27-yard field goal.
2:00 – Needing seven on fourth down, the Colts got eight to move the chains.
1:28 – Luck tossed a short pass to Hilton, who then took it into the end zone for a 63-yard score. The two-point conversion fell incomplete, so the score stayed at 26-22.
1:11 – Rivers found Henry who took the ball upfield. However, Clayton Geathers came in to pop the ball free from Henry's arms and the Colts recovered the fumble.