Notable Players: QB Jimmy Garoppolo, WR Ray-Ray McCloud, TE George Kittle, WR Deebo Samuel, DL Nick Bosa, T Trent Williams, DL Dee Ford, WR Brandon Aiyuk.
The first matchup between these two teams was on September 17, 1972, the 49ers took a 34-3 win over the Chargers.
The last matchup between these two teams was on November 13, 2022, where the 49ers took a 22-16 win over the Chargers.
Photos Throughout the Years
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